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The results of the MTT assay showed that overexpression of ATF4 significantly promoted the proliferation of HuOCSCs in vitro and reduced the cell proliferation inhibition rate (Figure 6A)

Hberle J, Burlina A, Chakrapani A, Dixon M, Karall D, Lindner M, Mandel H, Martinelli D, Pintos-Morell G, Santer R, Skouma A, Servais A, Tal G, Rubio V, Huemer M, Dionisi-Vici C (2019) Suggested guidelines for the diagnosis and management of urea cycle disorders: first revision

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Isoprostane (IsoP) is considered as a gold standard marker of in vivo oxidative stress and also a measure of environmental redox status by inducing inflammation and atherosclerosis through activation of mitogen-activated protein (MAP) kinase in many human diseases, i.e., periodontitis disease and chronic kidney disease 12,13,14,15,16